Fletcher factor deficiency: family study and detection.

Eight of 1 1 children of a known Fletcher taming celite or kaolin were sensitive to factor-deficient individual were found to Fletcher factor deficiency, while one rehave normal activated partial thromboagent containing ellagic acid did not deplastin times, normal levels of factors VIII, tect this abnormality. The finding of an IX, Xl, and XII, and a mean Fletcher factor abnormal partial thromboplastin time that level of 53% (range 40%-72%), sugis corrected by a 10-mm incubation period gesting a heterozygous state for the geneis presumptive evidence for Fletcher factor controlling Fletcher factor production. All deficiency. partial thromboplastin time reagents con-